ralph lauren hoody: Familiar local name in snow sports returns

For more than three decades, Mt. Pilchuck Ski & Sport in Everett was a mecca for skiing and snowboarding enthusiasts in the Northwest. Now, a year after its owner retired and closed the store, the well-known name lives again in a new Arlington business that offers the same kind of friendly environment, quality products and personalized customer care.

"The former owner was so pleased that the name would continue and encouraged us to set up our business as Mt. Pilchuck Ski & Sport," said Lynn Marks, CEO of the business she owns with her husband, Bentley. The couple lives in Arlington.

Opened a few weeks ago on 172nd Street NE near the Arlington Airport, the store sells its own line of skis and snowboards, plus jackets, hats and other winter sports products and accessories. There's a table-and-chair lounging area styled as a mountain cabin, plus hand-made products from area residents, including knitted hats and beaded bracelets.

Local response has been good, according to the owners,There are tons of canada goose jacket discount around nys. who have hired Arlington High School students to help out. The store waxes and tunes skis and snowboards on site. Open year-around, the store will carry wake boards and long boards, tubes for river floats, camping gear, backpacks and fly fishing and golfing equipment.

"We also want to have kite flying contests and let kids design their own kites," Lynn Marks said.

The business is a sales contact for InterShelter domed buildings (www.intershelter.com). The buildings are designed to provide quickly assembled housing for areas ravaged by hurricanes and tornadoes but are just as useful as mountain or lakeside recreation homes.

Behind the launch of the Marks' Mt. Pilchuck Ski & Sport venture was the Markses' dream of promoting their patented invention, the iCycle Yeti, that features a bicycle-like frame with handlebars and snowboards instead of wheels.

It's been a long struggle for the Markses to see their downhill snow scooter become popular. The Yeti blends the attractions of snowboarding and biking to create a new snow experience.

Eleven years ago in Snohomish, Bentley Marks watched his niece ride a Razor scooter and began thinking about creating something similar for the snow sport industry.

"The first one built in my garage weighed 69 pounds," said Bentley Marks, a former airline pilot. "When we tested it in Nevada, we proved the concept worked but it shook when it went too fast. One fellow who looked at it helped us re-engineer the frame and an engineer doing freelance CAD work helped to fine-tune it."

After producing a much lighter version and finding a manufacturer, the couple founded The Slider Corp. to market the Yeti and began promoting it, attracting the attention of the national television program "Heartbeat of America," hosted by William Shatner. Their website also notes publicity on KING-TV's "Evening Magazine," in Ski Area Management magazine, online at Skipressworld.com and in local publications.

Source: http://ralphlaurenhoody.blogspot.com/2012/02/familiar-local-name-in-snow-sports.html

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Our Web Hosting - Personal finance advice and credit counseling

You may need to do a little extra prepping for your car so it is ready for the winter months. Conditions that come about during the winter months, especially during severe weather conditions, are not the same than other times of the year. For those who have a newer car or truck, it may not really matter much but you should still be cautious. You are not quite finished learning about Car wheels and all that it means in your life. We encourage you to seriously look at the backdrop of your own life and how what you are reading about will help. It goes without saying that we have no real idea about how this is playing out for you, so we just try to present solid information. Obviously it would be great to have a very well-rounded grasp on things. So, just take it a little at a time and learn from the best sources which is always best. Since you know what you need about this, then be careful you do not waste time in other areas. When you do locate what is meaningful to you, then obviously you will be compelled to focus on that. You can save a significant amount of money if you decide to implement all of these tips, or at least some of them.

The cold temperatures might cause your winter tires to deflate quickly so keep an eye on the pressure regularly. You will get better gas mileage when your tire has the right pressure, and it will give you a less chance of getting a flat tire. You should also avoid having your gas tank run below the quarter mark. Originally this was accomplished on older cars to make sure there were no frozen gas lines, but it is not as common with newer vehicles. You need to keep enough gas in the tank, in case you become stranded. Along with that, you should carry an emergency package, which has cold weather gear such as gloves and hats. The package also needs to have flares, flashlight, jumper cables plus some tools.

You should also look at the fluid levels before wintertime rolls around. You actually should check your cooling system, especially when living in a place the temperatures get below freezing. Numerous pricey engine failures are the result of an improperly maintained cooling system. Be certain your antifreeze is satisfactory and check it all through the winter. You should also include non-freezing liquid for your auto glass washer. You should also have your electric battery checked to find out if it can last through the winter. But let?s keep going because we have some exceptional tips for you to give serious attention. Get rid of any corrosion on your battery power terminals, or your car may not start. shelf-life of a battery is reduced with extreme cold weather. And be sure that you have jumper cables readily available in your car.

It is recommended to have your oil changed before winter even if it is not time yet. When it comes to an older vehicle, you may want to use a light weight oil to keep parts lubricated in the cold weather. New cars already use lighter oil making it not an issue. They don?t always go on that long during extremely cold winters, but you can still start off with new wiper blades. These new blades can keep your windshield cleaner with the ice and slush, and clean windows are important. You will want excellent traction in the winter months, so get your snow tires on. At a minimum use a very good all season radial tire.

You want to be sure that you are ready before the winter weather rolls in. When you delay too long you may get stuck in an early winter storm. You?ll want to plan in advance and start working on it now.

Source: http://www.solutionsdebtmanagement.com/will-be-compelled-to/

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The Ultimate Test of Siri's Accent-Deciphering Skills: Scotland [Video]

Siri has been tested in the interpretation of accents across the country, but she meets her match with the utterly amazing dialect of the proud Scottish people. To be fair, how many actual humans would know how to respond to a request for a "jammy dodger like a f*ckin jam sandwich"? More »

Source: http://feeds.gawker.com/~r/gizmodo/full/~3/Z9TPKBz56ho/the-ultimate-test-of-siris-accent+deciphering-skills-scotland

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LB CCC ? Yoga, Pilates Studio, And Health and fitness center ...

So that you can get one?s overall body toned up into good form, heading to some pilates studio, practising yoga or operating out on the fitness center could all be the answer. Training can help a person?s bodily system and mental overall health likewise. Studies have revealed that executing common exercise can be far more successful for the treatment of despair and anxiety than prescription medication. Now which is a little something to have pumped up about. Satisfied and toned people lead extra effective lives. Getting the right gym equipment for your activities may help in obtaining physical fitness aims. Below are some factors to think about:

- Sneakers: Based over the regime, shoes could or might not be required. For functioning out with weights and on devices these kinds of as stair-steppers and elliptical trainers, a well fitting and flexible athletic shoe is a need to. Most gyms will not even permit an individual out within the ground devoid of foot coverings. Having a adaptable rubberized bottom enables a participant to own support and bendability as well. Runners and walkers must have the right shoe so as to defend and assistance their toes, likewise. Yoga and pilates participants might desire to go barefoot. As a way to do particular poses, a bare foot may possibly grip the mat?s floor additional efficiently.

- Mat: For yoga and pilates, a sticky mat is critical so that you can conduct lots of of the poses together with to provide ease and comfort. There are actually a range of thicknesses and colours available and personal preferences must mandate the choice.

- Tote bag: A slender tote bag will have a rolled up sticky mat just good. Having a number of pockets for private goods is going to be a fantastic addition. This bag is often held inside the motor vehicle and prepared and waiting for a quit in the health club.

- Work out clothes: Comfy, non-binding, airy clothing is very best for just about any workout regimen. Restrictive outfits will inhibit movement and make the exerciser disappointed because of the impingement. Yogis could wish to select leotard like pants and tops to be able to have versatility and liberty of movement. Baggy shirts and pants may get within the method of poses. It is really a good idea to hold a list of workout apparel in the car or truck whatsoever instances so a fast excursion to the gym can always transpire without setting up for it.

- Water bottle: A top quality h2o bottle is necessary for preserving hydrated. A steel or tricky plastic container may perhaps be ideal but it really is a good idea to ensure it is a content which will not likely break down in very hot or chilly temps. Plastic that may be decreased high quality will launch chemical compounds into your water if it can be frozen or heated when still left within a motor vehicle. By no means freeze the disposable drinking water bottles obtained at the supermarket in order to have amazing H2O the next day. This is certainly dangerous to some person?s overall health.

Enrolling in the pilates studio, training yoga or doing exercises at the fitness center can change a person?s physique, perspective and complete life. Pair these regimes with a nutritious diet program comprised of lean proteins, refreshing veggies and fruits, whole grains and a great degree of perfectly remaining will probably be the outcome.

Source: http://lbccc.com/yoga-pilates-studio-and-health-and-fitness-center-machines

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Peyton Manning casts large shadow over Super Bowl (AP)

INDIANAPOLIS ? For a Manning who isn't in the Super Bowl, this one sure is making headlines.

It happened again Tuesday, when Colts quarterback Peyton Manning denied whispers that he was pondering retirement.

"I have no plans on doing that," he said.

It's the strongest indication that, despite having his third neck operation in September, he hopes to play in the NFL when the new season kicks off later this year ? something the league is happy about.

"My plan hasn't changed," he said. "I'm on track with what the doctors have told me to do, and I'm doing that. I'm rehabbing hard."

The NFL would prefer to keep the focus on this week's juiciest story lines -- Giants quarterback Eli Manning trying to outdo his older brother by winning a second Super Bowl; Patriots quarterback Tom Brady and coach Bill Belichick chasing their fourth titles and maybe exacting a little revenge for their loss to New York four years ago.

But as everyone knows, this is Peyton's place, his town, and fans hang on every detail of his recovery.

"It's not the way it should be," he said earlier Tuesday in a taped interview with ESPN.

The Colts ended their most tumultuous month in more than a decade with another flurry of moves.

Team officials confirmed Tuesday that they had hired Bruce Arians, Manning's former quarterbacks coach, as offensive coordinator, and Harold Goodwin as offensive line coach. They also fired tight ends coach Ricky Thomas and assistant offensive line coach Ron Prince.

The whirlwind of changes began Jan. 2, the day after the Colts clinched the No. 1 overall draft pick with a league-worst 2-14 record. Irsay has since fired vice chairman Bill Polian, general manager Chris Polian, and dismissed coach Jim Caldwell and most of his staff -- a series of changes that prompted Peyton Manning to voice his complaints two days after the conference championship games.

Two days later, Irsay called Manning a "politician," fueling a public spat that drew national attention. The two tried to put out that fire before the team's scheduled arrivals, but the fallout has continued into this week.

"I would think he's very uncomfortable, especially with the Giants here and Eli," former Colts coach Tony Dungy said. "When you get to a Super Bowl, even though it's the second (recent) one for the Giants, you want the focus to be on that achievement. He would much rather have the focus on Eli and what they've done to get here, and unfortunately, that's not going to happen."

If there were any doubts, they were answered in a strange 24-hour period that began with the host committee's news conference Monday.

Irsay joined the mayor, governor and two committee officials to discuss game-week preparations, but wound up taking most of the questions, nearly all of which focused on Manning's future. Afterward, Irsay said he didn't plan to discuss the Manning situation again this week.

On Tuesday, Manning piped in.

Shortly after the NFL's annual Super Bowl media day event ended, Peyton Manning met with a small group of reporters with the idea of turning the attention back to Sunday's game.

That didn't work too well, either.

"I'm working hard, I had a really good session today," Manning said after repeatedly being asked about his rehab. "I continue to make progress and work hard. The doctors are encouraged and that's encouraging to me."

The four-time league MVP hasn't played in more than a year because of a damaged nerve that caused weakness in his throwing arm. He had neck surgery in May, then underwent his third and most invasive neck surgery in 19 months in September. Doctors fused two vertebrae together, a procedure that forced him to miss the Colts two-win season.

Since then, there has been rampant speculation about his recovery, the potential risks of a return, whether the Colts will pay Manning a $28 million roster bonus in early March to prevent him from becoming a free agent or whether the soon-to-be 36-year-old might retire.

"My plan hasn't changed," Manning said. "I'm on track with what the doctors have told me to do, and I'm doing that. I'm rehabbing hard."

Source: http://us.rd.yahoo.com/dailynews/rss/sports/*http%3A//news.yahoo.com/s/ap/20120201/ap_on_sp_fo_ne/fbn_super_bowl_peyton_s_shadow

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Jak of all trades? Not of leukaemia therapy!

Monday, January 30, 2012

About one in five or six cases of adult leukaemia in Western populations relates to so-called chronic myeloid leukaemia, or CML. Treatment of CML usually relies on inhibitors of the abnormal protein that causes the condition but some patients do not respond to treatment and efforts are underway to develop a supplementary approach, targeting the so-called JAK2 kinase. Recent results from the groups of Veronika Sexl at the University of Veterinary Medicine, Vienna (Vetmeduni Vienna) and Giulio Superti-Furga at the Research Center for Molecular Medicine of the Austrian Academy of Sciences (CeMM) have called this strategy into question. The work is published in the current issue of the prestigious journal Nature Chemical Biology and is of immediate relevance to leukaemia treatment.

The cause of CML has been known since 1960, when two scientists in Philadelphia, Pennsylvania showed that the disease was associated with a particular genetic abnormality, the "Philadelphia chromosome". Philadelphia chromosomes represent the result of an incorrect crossing-over between two chromosomes, through which part of the Bcr ("breakpoint cluster region") gene from chromosome 22 fuses with the Abl gene on chromosome 9. The fusion gene product is a tyrosine kinase, i.e. it can phosphorylate other proteins on tyrosine residues. When it does so, it incorrectly activates several signal pathways controlling cell division in white blood cells and leads to leukaemia. Thankfully, drugs have been developed that prevent the kinase activity of the BCR-ABL fusion protein and the majority of patients treated with such tyrosine kinase inhibitors (e.g. imatinib) show no further signs of leukaemia.

Unfortunately, however, patients may develop resistance to the therapy so an alternative approach is required. Recent developments have focused on the use of drugs targeting another kinase involved in CML, the JAK2 kinase. In normal white blood cells, JAK2 is known to activate a further molecule, known as STAT5, which is absolutely required for the development of CML. The argument runs that if JAK2 could be specifically inhibited ? and thus STAT5 not activated ? it would bring fresh hope to patients who do not respond to treatment with imatinib. Several potential inhibitors of JAK2 are currently undergoing clinical trials and may shortly be available for treating patients.

The theory is appealing but to date we do not really understand exactly what happens when JAK2 is inactivated following the initiation of leukaemia by the Bcr-Abl oncogene. Sexl and her colleagues have used a transgenic mouse model to clarify the functions of these proteins in leukaemia. Their results were highly unexpected. The JAK2 kinase was found to be not required for the maintenance of the disease, i.e. inhibiting JAK2 in leukaemic cells had no therapeutic benefit. However, inhibition of STAT5 in leukaemia was sufficient to prevent cell proliferation. As Sexl says, "this means that the normal signalling pathway is completely rewired in CML cells: STAT5 activity no longer depends on JAK2." In support of this conclusion, the researchers were able to show that the BCR-ABL protein directly phosphorylates STAT5, thereby activating it.

As Superti-Furga notes, "The findings have extremely important consequences for CML therapy in humans," adding, "We are very happy that the collaboration between our two groups is so fruitful". Put bluntly, leukaemia patients that do not respond to imatinib will not be helped by inhibiting JAK2. Interestingly, some JAK2 inhibitors do slow the progression of leukaemic cells, although they must be given at very high levels. The "therapeutic" action is mediated by a secondary target of the JAK2 inhibitors, which Sexl and colleagues have shown to be the Bcr-Abl oncogene itself. Sexl concludes that, "at the moment there is simply no rationale for giving leukaemic patients JAK2 inhibitors. If we want to help patients who do not respond to imatinib, we should concentrate instead on developing inhibitors to STAT5."

###

University of Veterinary Medicine -- Vienna: http://www.vetmeduni.ac.at

Thanks to University of Veterinary Medicine -- Vienna for this article.

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Source: http://www.labspaces.net/117176/Jak_of_all_trades___Not_of_leukaemia_therapy_

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HBT: Is identity fraud rampant in baseball?

In the wake of the ?Leo Nunez? and ?Fausto Carmona? identity fraud incidents, the New York Times has a story in which people around baseball talk about how widespread the problem is feared to be:

Few in baseball were surprised that two well-established players had misrepresented themselves. The fear is that the problem could be much more widespread. One agent said more than a dozen players could soon lose their contracts because of age and identity issues.

?These are like time bombs,? Mark Newman, the Yankees? senior vice president for baseball operations, said by telephone from the Dominican Republic while scouting there last week.

For his part Newman, as well as others in baseball, believe that the problem will get better. Still: as long as there are millions to be gained by an 18 or 19 year-old passing himself off as 16, this problem is going to persist.

Source: http://hardballtalk.nbcsports.com/2012/01/29/dominican-players-and-identity-fraud-these-are-like-time-bombs/related/

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